| Customization: | Available |
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| CAS No.: | 551-68-8 |
| Formula: | C6h12o6 |
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Aloxose (English: psicose), classified as hexose and ketose, is the differential isomer corresponding to the carbon at position three of d - fructose, IUPAC name (3R,4R,5R)-1,3,4,5,6 - pentahydroxyhexan-2 -one. Some of the product information is listed below:
Numbering system: CAS No. 551-68-8; MDL No. MFCD00083478; EINECS No. 208-999-7; PubChem No. 24898906
Molecular structure data: molar refractive index 37.42; molar volume 113.3 (m³/mol); isotonic specific volume (90.2K) 351.7; surface tension 92.65 (dyne/cm); polarizability 14.83 (10-²4cm³)
Properties and stability: stable at room temperature and pressure
Synthesis method: mainly prepared by using enzyme immobilization and conversion method, i.e. cloning and expression of the enzyme, isolation and refinement, and then conversion by appropriate carrier immobilization
Sweetness: about 70% of sucrose.
Calorie: very low calorie, FDA stipulates that its calorie is 0.4kcal/g.
Physiological functions:
Effects on lipid metabolism: It can reduce body weight and fat accumulation in the body, reduce the size of fat cells, and its ability to reduce fat accumulation may be realized by inhibiting fat synthesis and increasing the rate of fat decomposition;
Effect on blood glucose metabolism: it has the effect of lowering blood glucose, which will be absorbed into the blood through the small intestine and then discharged by the kidneys after oral intake, and will not cause fluctuations in blood glucose, and it can also inhibit the activity of α-glucosidase;
Antidiabetic mechanism: It can induce the expression of hepatic glucokinase, improve the synthesis of hepatic glycogen, slow down the fibrosis of β pancreatic islet cells, and its antidiabetic effect is mainly realized by maintaining blood glucose level, reducing weight gain, controlling postprandial blood glucose, reducing inflammatory reaction, and lowering the level of glycosylated hemoglobin;
Others: It can scavenge reactive oxygen radicals more effectively, and has neuroprotective effects on 6 - hydroxydopamine-induced apoptosis, and also inhibits the expression of monocyte chemotactic protein MCP-1 induced by high glucose concentration, which has the potential function of treating the degeneration of neural tissues and atherosclerosis and other related diseases.
Key Values:
Pharmaceutical field: It can inhibit fatty liver enzymes and intestinal α-glucosidase, thus reducing the accumulation of body fat and inhibiting the rise of blood glucose concentration;
Food field: with the advantages of high sweetness, good solubility, low calorie and low glycemic response, it is considered as one of the most ideal sucrose substitutes. Adding Alozone Sugar to food not only improves its gelatinization, but also improves its flavor by having a Meladic reaction with food proteins. Compared to d-fructose and d-glucose, alloxan produces more antioxidant melamine products and maintains the antioxidant level of the food for a longer period of time.In 2011, alloxan was certified safe by the FDA for use as an additive in food and dietary applications.
Research progress: Chemical preparation of allulose has not yet achieved a breakthrough due to complicated product purification steps, serious chemical contamination, and numerous by-products. Bioconversion methods have gradually become the main strategy for the production of allulose due to the advantages of single reaction and simple purification steps. Among them, ketose 3-differential isomerase, as an important catalyst for the bioconversion of allulose, can catalyze the interconversion of d-fructose with d-allulose and d-tagatose with d-sorbose.
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