Product Description
Basic Information
Chemical Name: alpha - Lipoic Acid, which is a sulfur-containing fatty acid. A purity of 99% indicates that the content of alpha - Lipoic Acid in this product is quite high.
Molecular Weight: Approximately 206.33.
CAS Registry Number: 1077 - 28 - 7.
Source and Production
Source:
- In living organisms: In living organisms, alpha - Lipoic Acid serves as a coenzyme for pyruvate dehydrogenase and alpha - ketoglutarate dehydrogenase complexes in mitochondria and participates in the cellular energy metabolism process. It can be synthesized in certain microorganisms and plants. Animals can also obtain or synthesize a small amount of alpha - Lipoic Acid through food intake or their own synthesis within the body.
- Chemical synthesis: High-purity alpha - Lipoic Acid is mainly produced through chemical synthesis methods. Starting from adipic acid and other raw materials, the molecular structure of alpha - Lipoic Acid is constructed through a series of complex organic chemical reactions, such as cyclization, oxidation, and sulfuration steps.
Physical Properties
Appearance: It is usually in the form of light yellow crystalline powder. The crystal particles are relatively uniform in size and may have a certain luster under light.
Solubility: It has a relatively low solubility in water, around 1 g/L. However, it has better solubility in organic solvents such as ethanol, methanol, and chloroform. This difference in solubility leads to different handling methods in various formulations and application scenarios.
Melting Point: It is approximately between 60 - 62 °C. The melting point range can be used for preliminary judgment of the product's purity. Near the melting point, solid alpha - Lipoic Acid will gradually turn into a liquid state.
Chemical Properties
Stability: It is relatively stable under normal temperature and pressure. However, oxidation reactions may occur under light, high temperature, or high humidity conditions. Due to the presence of sulfur atoms, it is prone to oxidation, especially in the presence of oxygen and metal ions, and the oxidation rate may accelerate.
Acidic Properties: The alpha - Lipoic Acid molecule contains a carboxyl group and thus has acidic properties. It can undergo a neutralization reaction with bases to generate corresponding salts. For example, when reacting with sodium hydroxide, sodium lipoate can be produced.
Redox Properties: alpha - Lipoic Acid has unique redox characteristics. It can be converted between the disulfide bond (- S - S -) and the thiol group (- SH). In the oxidized state, it exists in the form of a disulfide bond; in the reduced state, the disulfide bond is broken to form two thiol groups. These redox characteristics enable it to play a crucial role in the intracellular antioxidant process and energy metabolism.
Quality Standards and Detection
Purity Detection: Besides the labeled 99% purity, precise analytical methods such as High-Performance Liquid Chromatography (HPLC) are used to accurately measure the content of alpha - Lipoic Acid. Meanwhile, other impurity components, including incompletely reacted raw materials and by-products during the synthesis process, will also be detected.
Heavy Metal Detection: Strict detection is carried out on heavy metal elements such as lead, mercury, and cadmium in the product to ensure that their contents meet relevant standards. Excessive heavy metal content may have toxic effects on the human body and affect organs such as the nervous system, liver, and kidneys.
Microbial Limit Detection: The numbers of microorganisms such as bacteria, molds, and yeasts in the product are detected, and limits are set. For example, the total number of bacteria is generally required to not exceed 1000 CFU/g (colony-forming units per gram) to ensure the safety and quality stability of the product.
Functions and Applications
Healthcare Functions:
- Antioxidant Effect: alpha - Lipoic Acid is a powerful antioxidant. It can scavenge free radicals in the body, such as superoxide anion radicals and hydroxyl radicals. Its antioxidant effect is more extensive than that of vitamin C and vitamin E because it can play an antioxidant role in both aqueous and lipid phases, protecting cell membranes, mitochondria and other structures from free radical damage and reducing oxidative stress reactions.
- Improvement of Diabetes Complications: In the treatment of diabetes, alpha - Lipoic Acid helps to improve complications such as diabetic neuropathy. It can promote nerve regeneration and repair and relieve symptoms such as nerve pain and numbness. This is because alpha - Lipoic Acid can improve the blood circulation of nerves and increase the nutritional supply in the nerve endomembrane.
Application Fields:
- Health Product Industry: alpha - Lipoic Acid with a purity of 99% is mainly applied in the health product field, appearing in dosage forms such as capsules and tablets. After consumers take it, it can be used for antioxidant, improving immunity, and improving physical functions and other health care purposes.
- Medical Field: In the medical field, alpha - Lipoic Acid is used to treat diseases such as diabetic peripheral neuropathy. It can also be used as an auxiliary component of other drugs to enhance the antioxidant and treatment effects of drugs.
Dosage and Usage Recommendations
Dosage Range: For health care purposes, the dosage of alpha - Lipoic Acid is generally between 100 - 600 mg per day. When used to treat diseases such as diabetic neuropathy, the dosage may vary according to the severity of the disease, generally between 600 - 1800 mg per day. The specific dosage should be adjusted according to the doctor's advice.
Usage Method: It is usually taken orally and absorbed into the bloodstream through the gastrointestinal tract. In some cases, injection methods such as intravenous injection or intramuscular injection can also be adopted, but this is usually carried out by professional personnel in a hospital or other medical environment.
Storage and Transportation
Storage Conditions: It should be stored in a cool, dry, and dark environment. It is best to place it in a well-sealed container, such as a brown glass bottle or aluminum foil bag, to prevent oxidation and moisture absorption. The ideal storage temperature is between 2 - 8 °C.
Transportation Requirements: During transportation, avoid high temperatures, sunlight, and rain. Use appropriate packaging materials, such as sealing plastic bottles and then adding outer packaging such as carton boxes, and placing desiccants inside the packaging to ensure the quality stability of the product during transportation.
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