Colchicine Powder for Arthritis Treatment and Joint Support

• Customization: Available
• CAS No.: 64-86-8
• Resource: Natural
• Model NO.: 64-86-8
• Transport Package: Bag
• Specification: 25kg/50kg
• Trademark: //
• Origin: China
• Production Capacity: 500000t

Product Description

 

Product Description

Basic Information

 

• Source: Colchicine is mainly an alkaloid extracted from the corms and seeds of the plant Colchicum autumnale L. (Liliaceae). It can also be prepared by chemical synthesis methods.
• Chemical Name: N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[α]heptalene-7-yl)acetamide.
• Appearance: Pure colchicine appears as pale yellow needle-like crystals, odorless, and its color will darken when exposed to light.
• Melting Point: Around 157 °C.

Components and Purity

 

• Main Component: Colchicine is the core component. A purity of 98% means that colchicine accounts for 98% of the total components in the product, and the remaining 2% may contain a small amount of impurities, such as other alkaloids and residual solvents in the extraction process.
• Impurity Situation: The types and contents of impurities vary depending on the extraction and preparation methods. High-quality products will strictly control impurities. For example, the contents of heavy metals (such as lead and mercury) are generally required to be at an extremely low level to ensure safety and effectiveness.

Specifications

 

• Content Specification: 98% colchicine is a high-purity specification. This high-purity product is applicable to fields such as medicine where high accuracy of component requirements is needed.
• Packaging Specification: Common packaging includes 1 kg/bottle, 5 kg/drum, etc., which are used for industrial or large-quantity wholesale packaging. There are also small-dose packaging such as 100 mg/bottle and 500 mg/bottle, which are used for laboratory research or medical use.

Quality Standards

 

• Detection Methods:
  • High-performance liquid chromatography (HPLC) is commonly used to detect the content and purity of colchicine. By injecting the sample into the liquid chromatograph and comparing it with the chromatogram of the standard product, the content of colchicine can be accurately determined to see if it reaches 98%.
  • The melting point determination method is also used as an auxiliary detection method, because pure colchicine has a fixed melting point range, and the purity of the product can be preliminarily judged by measuring the melting point.
• Quality Indicators:
  • The content of related substances is strictly limited. The content of a single impurity is generally required to not exceed 0.5% - 1%, and the total impurities (the sum of components other than colchicine) are not allowed to exceed 2%.
  • The loss on drying is usually required to be less than 0.5% to ensure that the product does not contain excessive moisture and to guarantee the stability of quality.
  • The residue on ignition (mainly inorganic impurities) is generally limited to 0.1% - 0.2%.

Efficacy and Functions

 

• Medical Uses:
  • Anti-inflammatory Effect: Colchicine is a classic drug for the acute attack of gouty arthritis. It reduces the release of inflammatory mediators by inhibiting the chemotaxis, adhesion and phagocytosis of neutrophils, thereby alleviating the inflammatory symptoms such as redness, swelling, heat and pain of joints. For example, during a gout attack, colchicine can relieve joint pain in a short time, and symptom improvement can usually be seen within a few hours after taking the medicine.
  • Antitumor Effect: Colchicine can inhibit cell mitosis, arrest the cell cycle in the metaphase, and interfere with the formation of the spindle apparatus, thus inhibiting the proliferation of tumor cells. However, due to its relatively high toxicity, its application in tumor treatment is relatively complicated, and it is mostly used as a research tool drug or in combination with other chemotherapy drugs.
  • Antifibrotic Effect: In the research on some fibrotic diseases such as liver fibrosis and lung fibrosis, it has been found that colchicine may play an antifibrotic role by regulating the synthesis and degradation of the extracellular matrix and inhibiting the proliferation and activation of fibroblasts.

Application Fields

 

• Medical Field:
  • It is used to prepare drugs for treating gout, such as colchicine tablets. These drugs can effectively relieve the pain and inflammation during the acute attack of gout.
  • In the research on tumor treatment, it is used as an experimental drug to explore new treatment regimens, especially for some types of tumors with active proliferation, such as leukemia.
• Scientific Research Field: In cell biology and pharmacology research, colchicine is used as a tool drug to study cell cycle, spindle apparatus formation and other cellular physiological processes. For example, in cell culture experiments, adding colchicine can make cells arrest in the metaphase of mitosis, facilitating researchers to observe the morphology of chromosomes and so on.

 

 

 

 

 

 

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