Product Description
Basic Information
Chemical Name: 3',4',5,7 - Tetrahydroxyflavone.
Aliases: Yellow flavin, Huangshiling, etc.
English Name: Luteolin.
CAS Number: 491-70-3.
Chemical Formula: C15H10O6.
Molecular Weight: 286.23.
Physical and Chemical Properties
Appearance: Yellow needle-like crystals or yellow-green powder.
Density: 1.654g/cm³.
Melting Point: 330ºC.
Boiling Point: 616.1°C at 760 mmHg.
Flash Point: 239.5°C.
Vapor Pressure: 9.03E-16mmHg at 25°C.
Solubility: Slightly soluble in water, weakly acidic, soluble in alkaline solutions, ethanol, methanol, DMSO and other organic solvents.
Natural Sources
It is widely distributed in a variety of plants, such as natural medicinal materials like Honeysuckle, Chrysanthemum, Schizonepeta tenuifolia, Ajuga decumbens, Artichoke, Perilla genus, Scutellaria genus, Callicarpa nudiflora, as well as vegetable fruits like Brussels sprouts, Cabbage, Cauliflower, Beet, Broccoli, Carrot, Celery, Sweet pepper, Chili pepper, Peanut, etc.
Production Processes
Extraction and Purification: Organic solvents such as methanol, ethanol, and acetone are used for reflux extraction from medicinal materials rich in luteolin. After the extraction liquid is concentrated under reduced pressure, pure products are obtained through steps such as extraction and degreasing, column adsorption, elution, and recrystallization.
Semi-synthetic Route: Using hesperidin extracted from orange peel as a raw material, luteolin is obtained through three-step reactions including dehydrogenation, hydrolysis of deglycosylation, and demethylation.
Total Synthesis Route: Using phloroglucinol as a raw material, luteolin is synthesized through multiple-step reactions.
Biosynthesis: By constructing a 4-step recombinant flavanone pathway in Saccharomyces cerevisiae and introducing flavone synthase into the strain, phenolic propanoic acid precursors are converted into luteolin.
Pharmacological Activities
Anti-inflammatory: It inhibits the release of inflammatory mediators and alleviates inflammatory reactions, and has a therapeutic effect on inflammatory diseases such as arthritis and chronic enteritis.
Anti-allergic: It inhibits the release of allergic reaction mediators and alleviates allergic symptoms, and has a preventive and treatment effect on allergic diseases such as allergic rhinitis and asthma.
Anti-tumor: It inhibits the growth and proliferation of tumor cells and has a certain effect on various tumors such as prostate cancer, breast cancer, colon cancer, and ovarian cancer.
Anti-fibrosis: It reduces the degree of liver fibrosis and improves the histopathological changes of pulmonary fibrosis caused by bleomycin.
Antioxidant: It scavenges free radicals in the body and slows down aging and oxidative damage.
Product Specifications and Prices
Common product specifications of luteolin on the market include 98% area normalization method and 98% external standard method, etc. The price usually ranges from 240 yuan to 2,300 yuan per kilogram.
Application Range
Medical Field: It is used for relieving cough, expelling phlegm, reducing inflammation, and treating cardiovascular diseases, amyotrophic lateral sclerosis, SARS, hepatitis, etc.
Health Product Field: It can be added as a functional ingredient with antioxidant, anti-inflammatory and anti-allergic effects.
Cosmetics Field: With antioxidant and anti-inflammatory effects, it can be used in skin care products.
Precautions
Luteolin has certain irritations to the eyes, respiratory system and skin. Appropriate protective clothing should be worn when using it. In case of accidental contact with the eyes, rinse immediately with plenty of water and consult a doctor.
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