Product Description
Basic Information
Chemical Name: Nicotinamide Riboside, abbreviated as NR. A purity of 99.5% indicates that the proportion of the NR component in the product is extremely high.
Molecular Weight: Approximately 255.25.
CAS Registry Number: 1341 - 23 - 7.
Source and Production
Source:
- In living organisms: In living organisms, NR is a key precursor in the synthesis pathway of Nicotinamide Adenine Dinucleotide (NAD+). It can be converted into NAD+ through specific enzymatic reactions and thus participates in numerous energy metabolism and signal transduction processes within cells.
- Food sources: Trace amounts of NR are present in some foods such as milk. However, the amount obtained from food is relatively limited.
Production Process:
- Chemical synthesis method: The molecular structure of NR is constructed through organic chemical synthesis. This method enables precise control of reaction steps, but it may produce some chemical impurities and requires a complex purification process to achieve a purity of 99.5%.
- Bio-fermentation method: Utilize microbial fermentation technology to enable microorganisms to synthesize NR in a suitable culture medium. The NR produced by this method is relatively closer to its natural form. Moreover, after appropriate separation and purification processes, high-purity products can be obtained.
Physical Properties
Appearance: It is generally in the form of white crystalline powder. The powder particles are relatively uniform and have good fluidity.
Solubility: It is readily soluble in water and can quickly dissolve in water to form a clear solution. This makes it convenient for processing into various dosage forms in the pharmaceutical and health product industries, such as oral liquids and injections. It also has a certain degree of solubility in organic solvents (such as ethanol and acetone), but its solubility in these solvents is poorer than that in water.
Melting Point: It is approximately between 122 - 124 °C. The range of the melting point can be used as a reference indicator for product quality control to judge the purity and quality stability of the product.
Chemical Properties
Stability: It is relatively stable under normal temperature and dry conditions. However, under conditions such as high temperature, high humidity, or strong light irradiation, its chemical structure may change. For example, when exposed to a high-temperature environment for a long time, NR may undergo decomposition reactions and generate other compounds, thereby affecting its efficacy.
Redox Properties: As a precursor of NAD+, NR plays a crucial role in the intracellular redox metabolism process. It can participate in a series of electron transfer reactions. Under the catalysis of appropriate enzymes, it can transfer electrons to other molecules, promote the synthesis and regeneration of NAD+, and then participate in the energy metabolism process of cells, such as mitochondrial respiration.
Acid-base Reaction: The NR molecule contains functional groups such as amino groups and hydroxyl groups, which endow it with certain acid-base properties. In an acidic environment, the amino group may undergo a protonation reaction; in an alkaline environment, the hydroxyl group may participate in acid-base neutralization reactions, etc. These reactions will affect the existing form and chemical activity of NR in the solution.
Quality Standards and Detection
Purity Detection: Besides the labeled 99.5% purity, precise analytical techniques such as High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) need to be used to accurately measure the content of NR to ensure that the product meets the high-purity quality requirements. Meanwhile, other impurity components, including incompletely reacted raw materials and by-products, should be strictly detected.
Microbial Limit Detection: Microorganisms such as bacteria, molds, and yeasts in the product are detected, and limits on their quantities are set. For example, the total number of bacteria is usually required to be controlled at a relatively low level, such as not exceeding 100 CFU/g (colony-forming units per gram), to ensure the safety and stability of the product and prevent harm to human health caused by microbial contamination.
Heavy Metal Detection: Focus on detecting heavy metal elements such as lead, mercury, and cadmium in the product to ensure that their contents meet the relevant pharmaceutical or health product standards. Excessive heavy metal content may accumulate in the human body and cause damage to multiple organ systems of the human body (such as the nervous system, liver, and kidneys).
Functions and Applications
Healthcare Functions:
- Energy metabolism improvement: NR can effectively increase the intracellular NAD+ level. NAD+ plays a central role in the energy metabolism process of cells, such as participating in electron transfer and energy generation in glycolysis, the tricarboxylic acid cycle, and other links. By supplementing NR, the energy production of cells can be enhanced, fatigue can be alleviated, and physical functions can be improved.
- Anti-aging effect: As people age, the intracellular NAD+ level in the human body gradually decreases. As a precursor substance of NAD+, supplementing NR products with a purity of 99.5% can increase the synthesis of NAD+, activate proteins related to longevity (such as the Sirtuins family proteins), participate in processes such as DNA repair and gene expression regulation in cells, thereby playing a role in delaying aging and improving aging-related physiological indicators such as skin elasticity and cognitive function.
Application Fields:
- Health product industry: Products with 99.5% purity of NR are mainly applied in the high-end health product market. They are mainly in the form of capsules, tablets, oral liquids, and other dosage forms for consumers to take on a daily basis for the purposes of enhancing immunity, improving physical vitality, and relieving fatigue.
- Medical research field: As a potential drug research object, it is used to study the treatment of diseases related to aging, such as neurodegenerative diseases (Alzheimer's disease, Parkinson's disease), cardiovascular diseases, etc. In clinical trials, the improvement of disease symptoms and treatment mechanisms through the regulation of NAD+ levels are explored.
Dosage and Usage Recommendations
Dosage Range: The dosage of NR for healthcare purposes varies depending on individual differences (such as age, health status, and physiological needs). Generally speaking, the daily dosage is between 100 - 300 mg, but the specific dosage should be adjusted according to the advice of professional doctors or dietitians.
Usage Method: It is usually taken orally and absorbed into the bloodstream through the gastrointestinal tract. To improve the absorption efficiency, some products will adopt special formulation technologies, such as liposome encapsulation. During the use process, it is best to follow the product instructions or the guidance of professionals.
Storage and Transportation
Storage Conditions: It should be sealed and stored in a cool, dry, and dark environment. The ideal storage temperature is 2 - 8 °C. Well-sealed containers such as brown glass bottles or aluminum foil bags can be used for storage to prevent the product from being affected by moisture, oxidation, or light.
Transportation Requirements: During transportation, avoid high temperatures, sunlight, and rain. Adopt appropriate packaging materials, such as sealing plastic bottles and then adding outer packaging such as carton boxes, and adding moisture-proof and heat-insulating measures to ensure the quality stability of the product during transportation.
Company Profile
Our Advantages
Audited Supplier 
){kind=link}